Cushings

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Further reading:

Cushings Syndrome – Wikipedia article – (can lead to glaucoma and cateracts)

Cushings Disease – Wikipedia article – tumours on the pituitory gland (can lead to loss of periferal or side vision)

Cushings Disease is one of the CAUSES of Cushings Syndrome

Extract from Wikipedia article on Cushings: –

“Strictly, Cushing’s syndrome refers to excess cortisol of any etiology (as Syndrome means a group of symptoms). One of the causes of Cushing’s syndrome is a cortisol secreting adenoma in the cortex of the adrenal gland (primary hypercortisolism/hypercorticism). The adenoma causes cortisol levels in the blood to be very high, and negative feedback on the pituitary from the high cortisol levels causes ACTH levels to be very low.

“On the other hand, Cushing’s disease refers only to hypercortisolism secondary to excess production of ACTH from a corticotroph pituitary adenoma (secondary hypercortisolism/hypercorticism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism). This causes the blood ACTH levels to be elevated along with cortisol from the adrenal gland. The ACTH levels remain high because the tumor is unresponsive to negative feedback from high cortisol levels.”

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