Category Archives: Progressive Retinal Atrophy (PRA)

* A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever | Canine Genetics and Epidemiology

Source: Canine Genetics and Epidemiology

Author: Cathryn S Mellersh – cathryn.mellersh@aht.org.uk

Progressive retinal atrophy (PRA) is a group of inherited eye disorders that occur in many different dog breeds. Each form of PRA shows a simple pattern of mendelian inheritance, and is due to a mutation in one gene. However, over 20 different PRA-causing mutations have now been identified in a number of different genes. Some breeds, including Golden Retrievers (GR), may have more than one genetic form of PRA.

Canine PRA is considered to be the equivalent of Retinitis Pigmentosa (RP), which is a group of inherited human eye diseases.

This paper has identified a gene called TTC8 that is Continue reading